BDBM50247349 CHEMBL4072005
SMILES c1cc2cnccc2cc1NC(=O)NCC(=O)N3CCCC3
InChI Key InChIKey=DMIDPTCQPIJYFE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50247349
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of PRMT3 (unknown origin) using C-terminally biotinylated histone H4 as substrate in presence of [3H]S-adenosylmethionine by scintillation...More data for this Ligand-Target Pair
3D Structure (crystal)TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of PRMT3 (unknown origin) using C-terminal biotinylated histone H4 (1 to 24 residues) as substrate and SAM as cofactor in presence of [3H]...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKd: 53nMAssay Description:Binding affinity to PRMT3 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 21 residues) as substrate and SAM as cofactor preincubated for 20 mins followed by substr...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataKd: 85nMAssay Description:Binding affinity to biotinylated PRMT3 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of FLAG-tagged wild type human PRMT3 expressed in HEK293 cells assessed as decrease in exogenous H4R3 dimethylation level using GFP-tagged...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of wild type Flag-tagged human PRMT3 catalytic activity transfected in HEK293 cells assessed as inhibition of exogenous GFP-tagged H4R3 as...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 225nMAssay Description:Inhibition of FLAG-tagged wild type human PRMT3 expressed in HEK293 cells assessed as reduction in endogenous H4R3me2a level using GFP-tagged histone...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 225nMAssay Description:Inhibition of wild type Flag-tagged human PRMT3 catalytic activity transfected in HEK293 cells assessed as reduction in H4R3me2a level incubated for ...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: 1.30E+3nMAssay Description:Binding affinity to ePL-tagged human PRMT3 methyltransferase domain (211 to 531 residues) expressed in HEK293 cells assessed as protein stabilization...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: 1.60E+3nMAssay Description:Binding affinity to ePL-tagged human PRMT3 methyltransferase domain (211 to 531 residues) expressed in human A549 cells assessed as protein stabiliza...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: 1.80E+3nMAssay Description:Binding affinity to beta galactosidase fused human PRMT3 (211 to 531 residues) expressed in human HEK293 cells after 6 hrs by InCELL hunter assayMore data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 3(Human)
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Binding affinity to beta galactosidase fused human PRMT3 (211 to 531 residues) expressed in human A549 cells after 6 hrs by InCELL hunter assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Human)
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of [3H]LSD binding to 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair