BDBM50248608 CHEMBL4063358

SMILES CSc1sc(C(N)=O)c2CCc3cnn(C)c3-c12

InChI Key InChIKey=RXQSXUFJBOKCAT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248608   

TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248608(CHEMBL4063358)
Affinity DataIC50:  19nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248608(CHEMBL4063358)
Affinity DataIC50:  18nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248608(CHEMBL4063358)
Affinity DataEC50:  25nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed