BDBM50248859 2-(2,4-Difluoro-phenylamino)-10,11-dihydro-dibenzo[a,d]cyclohepten-5-one::CHEMBL515407

SMILES Fc1ccc(Nc2ccc3c(CCc4ccccc4C3=O)c2)c(F)c1

InChI Key InChIKey=ONKRGPPYJKVSHA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248859   

TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50248859(2-(2,4-Difluoro-phenylamino)-10,11-dihydro-dibenzo...)
Affinity DataIC50: 95nMAssay Description:Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50248859(2-(2,4-Difluoro-phenylamino)-10,11-dihydro-dibenzo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of p38alpha MAPK by cell-free enzyme immunosorbent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Eberhard-Karls-University T£Bingen

Curated by ChEMBL
LigandPNGBDBM50248859(2-(2,4-Difluoro-phenylamino)-10,11-dihydro-dibenzo...)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed