BDBM50249989 CHEMBL1387422

SMILES CC(CNC(=O)CCCn1nc(C)c2c(C)n(nc2c1=O)-c1ccc(C)cc1)c1ccccc1

InChI Key InChIKey=HZNKNJCWLQLQMJ-UHFFFAOYSA-N

Data  1 KI  6 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50249989   

TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd:  2.20nMAssay Description:Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd:  3.80nMAssay Description:Displacement of fluorescein-labeled Atorvastatin from N-terminal His6 tagged human recombinant PDE6D extracted from Escherichia coli BL21 star (DE3) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd:  8nMAssay Description:Inhibition of atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2019
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd:  8nMAssay Description:Binding affinity to PDEdelta (unknown origin) assessed as dissociation constant incubated for overnight by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd:  8nMAssay Description:Inhibition of Atrovastatin-PEG3-FITC binding to PDEdelta (unknown origin) incubated for 60 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKi:  8nMAssay Description:Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataKd: <10nMAssay Description:Binding affinity to PDEdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
University of Luxembourg

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataEC50:  1.80E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged K-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular K-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetGTPase HRas(Human)
University of Luxembourg

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataEC50:  5.00E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged H-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular H-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed