BDBM50250803 CHEMBL4083252

SMILES COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1

InChI Key InChIKey=RRTCFJGKAMKAIY-UHFFFAOYSA-N

Data  22 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50250803   

Target5-hydroxytryptamine receptor 1A(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in CHO-K1 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1A(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor transiently expressed in CHO cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting method relative to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125I]ABN from human dopamine D3 receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  6.5nMAssay Description:Displacement of [125I]IABN from recombinant human D3 receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H1 receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-pyrilamine from recombinant human H1 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintil...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2B(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1A adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  49nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1A adrenergic receptor measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-1B adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  94nMAssay Description:Displacement of [3H]-prazosin from recombinant human alpha1B adrenergic receptor transiently expressed in HEKT cells measured after 90 mins by microb...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 7(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2C(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  159nMAssay Description:Displacement of [3H]-mesulergine from recombinant human 5HT2C receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2A adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2B adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  241nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2B adrenergic receptor transiently expressed in HEKT cells measured after 90 mins by mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]ABN from human dopamine D2 long receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]IABN from recombinant human D2 long receptor stably expressed in HEK293 cell membranes measured after 60 mins by scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-2C adrenergic receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  433nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  577nMAssay Description:Displacement of [3H]N-methylspiperone from recombinant human D2 receptor stably expressed in fibroblast measured after 90 mins by microbeta scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  721nMAssay Description:Displacement of [3H]N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistamine H2 receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  871nMAssay Description:Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 2A(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  1.42E+3nMAssay Description:Displacement of [3H]-ketanserin from 5HT2A receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Target5-hydroxytryptamine receptor 1B(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  2.03E+3nMAssay Description:Displacement of [3H]-5-CT from recombinant human 5HT1B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(1B) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataKi:  3.02E+3nMAssay Description:Displacement of [3H]-SCH23390 from recombinant human D5 receptor transiently expressed in HEK cell membranes measured after 90 mins by microbeta scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  254nMAssay Description:Agonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(4) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  359nMAssay Description:Agonist activity at recombinant human D4 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(2) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataIC50:  328nMAssay Description:Antagonist activity at recombinant human D2 receptor expressed in CHOK1 cells assessed as inhibition of quinpirole-induced beta arrestin2 recruitment...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataIC50:  8.70nMAssay Description:Antagonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta arrestin2 recruitment p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetD(3) dopamine receptor(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50250803(CHEMBL4083252)
Affinity DataEC50:  167nMAssay Description:Agonist activity at recombinant human D3 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed