BDBM50251509 CHEMBL4064316

SMILES CC(C)n1cc(-c2ccncc2)c2ccncc12

InChI Key InChIKey=UIVOWAUHPLCYNK-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50251509   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251509(CHEMBL4064316 | US20250099442, Compound I.2)
Affinity DataIC50: 8nMAssay Description:Inhibition of full-length recombinant human GST-tagged Dyrk1a expressed in baculovirus expression system using Alexa-Fluor tracer-236 incubated for 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251509(CHEMBL4064316 | US20250099442, Compound I.2)
Affinity DataIC50: 10nMAssay Description:Assay Procedure1. Add 5 μL enzyme & substrate mixture to each well in Column 2-23 and A24-H24 wells of the 384-well assay plate;2. Add 5 μL 0% Phosph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2025
Entry Details
US Patent

TargetNuclear factor of activated T-cells, cytoplasmic 1(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251509(CHEMBL4064316 | US20250099442, Compound I.2)
Affinity DataEC50:  310nMAssay Description:Induction of nuclear translocation of human GFP-tagged NFATc1 expressed in virus infected primary human skeletal muscle myoblasts after 3 hrs by DAPI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50251509(CHEMBL4064316 | US20250099442, Compound I.2)
Affinity DataIC50: 660nMAssay Description:Inhibition of full-length recombinant human His-tagged GSK3B recombinant in baculovirus expression system using Alexa-Fluor tracer-236 incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed