BDBM50252767 (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydroxyethoxy)-ethyl]piperazin-1-yl}ethyl)oxime]::CHEMBL3216893::CHEMBL493657

SMILES OCCOCCN1CCN(CCO\N=C2\C(\Nc3ccccc\23)=C2\C(=O)Nc3cc(Br)ccc23)CC1

InChI Key InChIKey=WFQCEVIDLOLEDG-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50252767   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 34.1nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 500nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Athens

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 900nMAssay Description:Inhibition of CDK1/cyclin BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767(CHEMBL493657 | (2'Z-3'E)-6-Bromoindirubin-3'-[O-(2...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2020
Entry Details Article
PubMed