BDBM50253147 CHEMBL494305::N-Isopropyl-6-(6-methyl-3-(methylamino)benzo[d]isoxazol-7-yl)phthalazin-1-amine

SMILES CNc1noc2c(c(C)ccc12)-c1ccc2c(NC(C)C)nncc2c1

InChI Key InChIKey=ZWPJNBTUVZEJGC-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50253147   

TargetMitogen-activated protein kinase 14(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50253147(N-Isopropyl-6-(6-methyl-3-(methylamino)benzo[d]iso...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human recombinant GST-tagged p38alphaMAPK-induced ATF2 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50253147(N-Isopropyl-6-(6-methyl-3-(methylamino)benzo[d]iso...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed