BDBM50256478 CHEMBL507714::N-(2,6-difluorophenyl)-3-(3-(2-(2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide

SMILES COc1cc(ccc1Nc1nccc(n1)-c1c(nc2ccccn12)-c1cccc(c1)C(=O)Nc1c(F)cccc1F)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=HMXWMMRCKSDFCV-UHFFFAOYSA-N

Data  2 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50256478   

TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to insulin receptor by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity to IGF1R by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  36nMAssay Description:Inhibition of human IGF1R autophosphorylation in transfected mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  72nMAssay Description:Inhibition of ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  74nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  440nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAurora kinase A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin-like growth factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged IGF1R (957-1367) (unknown origin) expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetInsulin receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-tagged insulin receptor expressed in baculovirus by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50256478(CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...)
Affinity DataIC50:  57nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed