BDBM50257059 CHEMBL4082854

SMILES Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(Cl)cn1

InChI Key InChIKey=BDRDKDJERFXQSP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50257059   

TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 6.80nMAssay Description:Negative allosteric modulation of rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate induced-calcium mobilization prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 900nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using tacrine as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 1.64E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 8 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Institute of Imaging Science

Curated by ChEMBL
LigandPNGBDBM50257059(CHEMBL4082854)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using (R)-bufuralol as substrate preincubated for 15 mins measured after 8 mins in presence or absence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2019
Entry Details Article
PubMed