BDBM50257545 CHEMBL4067290

SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)-c1ccc(OC2CCOCC2)c(Cl)c1

InChI Key InChIKey=MWXQDEWVXWWKFT-UHFFFAOYSA-N

Data  1 KI  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50257545   

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257545(CHEMBL4067290)
Affinity DataKi:  5.20nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257545(CHEMBL4067290)
Affinity DataEC50:  38nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257545(CHEMBL4067290)
Affinity DataEC50:  89nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMetabotropic glutamate receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257545(CHEMBL4067290)
Affinity DataKd:  12nMAssay Description:Binding affinity to human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed