BDBM50258611 1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylethynyl)benzene::CHEMBL511603

SMILES Cc1nc(cs1)C#Cc1cc(F)cc(c1)-c1cccnc1

InChI Key InChIKey=YSZKSMMSKUUKKE-UHFFFAOYSA-N

Data  7 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50258611   

TargetMetabotropic glutamate receptor 5(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Displacement of [125I]RTI55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataKi: >6.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258611(1-Fluoro-3-(pyridin-3-yl)-5-(2-methylthiazol-4ylet...)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293A cells assessed as glutamate-induced calcium flux preincubated for 140 sec before glutamate cha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed