BDBM50258896 CHEMBL4060569::US11419874, TAK-915
SMILES COC[C@@H](NC(=O)N1CC(=O)Nc2cc(OC)cnc12)c1ccc(OC(F)(F)F)c(F)c1
InChI Key InChIKey=AWJSRXUQLSPAOI-CQSZACIVSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50258896
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged PDE1A expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cGMP as s...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE3A (669 to 1141 residues) expressed in baculovirus infected fall armyworm Sf9 cells using [3...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE5A1 expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cGMP as ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human N-terminal GST/C-terminal His-tagged PDE7B (109 to end residues) expressed in baculovirus infected fall armyworm Sf9 cells using ...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE9A2 expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cGMP as ...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length PDE10A2 transfected in African green monkey COS7 cells using [3H]cGMP as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE11A4 expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cGMP as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.49E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged PDE4D2 (2 to 507 residues) expressed in baculovirus infected fall armyworm Sf9 cells using [3H]...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged PDE8A1 expressed in baculovirus infected fall armyworm Sf9 cells using [3H]cAMP as ...More data for this Ligand-Target Pair
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Human)
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant human PDE6A/PDE6B expressed in insect cells using [3H]cGMP as substrate preincubated for 30 mins followed by substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 0.610nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair