BDBM50259963 CHEMBL4061944

SMILES CCNCc1cc(c(F)cc1F)[C@]1(C)CCSC(N)=N1

InChI Key InChIKey=PKEKOGWSIXFEBA-AWEZNQCLSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50259963   

TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259963(CHEMBL4061944)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACE1 in human H4 cells expressing wild type APP695 assessed as reduction in soluble APPbeta level after 18 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259963(CHEMBL4061944)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential after 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259963(CHEMBL4061944)
Affinity DataIC50:  7.57E+4nMAssay Description:Inhibition of BACE2 (unknown origin) by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50259963(CHEMBL4061944)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cathepsin D (unknown origin) by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed