BDBM50263057 CHEMBL381230

SMILES CN1C(=O)NC(Cc2c[nH]c3c(Cl)cccc23)C1=O

InChI Key InChIKey=WIKGAEMMNQTUGL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263057   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 320nMAssay Description:Inhibition of RIPK1 (1 to 312 residues) (unknown origin) preincubated for 15 mins followed by addition of [gamma32P] ATP and measured after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 754nMAssay Description:Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 910nMAssay Description:Inhibition of RIPK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50263057(CHEMBL381230)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed