BDBM50263093 6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-cyclopropylmethyl-amide::CHEMBL478649::N3-cyclopropyl-N4'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide::N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide

SMILES Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1

InChI Key InChIKey=BOPSUAHGQHFKGG-UHFFFAOYSA-N

Data  7 KI  22 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 50263093   

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  9nMAssay Description:Inhibition of human recombinant p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant His-tagged p38alpha-mediated ATF2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12nMAssay Description:Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  12.6nMAssay Description:Inhibition of GST-tagged p38alpha by fluorescence polarization methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 11(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataKi:  24nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19 transfected in Escherichia coli co-expressed with human NADPH reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 transfected in Escherichia coli co-expressed with human NADPH reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP3A4 transfected in Escherichia coli co-expressed with human NADPH reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human recombinant CYP2C9 transfected in Escherichia coli co-expressed with human NADPH reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHeat shock protein beta-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  53nMAssay Description:Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human PBMC preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of p38alpha-dependent TNFalpha production in human whole blood preincubated for 1 hr before LPS challenge by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  18nMAssay Description:Inhibition of p38alpha phosphorylation in IL1alpha-stimulated HLF cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.60E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase PLK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetSerine/threonine-protein kinase Sgk1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  75nMAssay Description:Displacement of rhodamine-green labelled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]pheny...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2 transfected in Escherichia coli co-expressed with human NADPH reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  75nMAssay Description:Inhibition of P38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank
MMDB
PDB3D3D Structure (crystal)

TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50263093(6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopr...)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed