BDBM50263495 CHEMBL4072818

SMILES O=C1CCc2ccccc2N1CCCN1CCC(Cc2ccccc2)CC1

InChI Key InChIKey=YCGXHEJETHPGPD-UHFFFAOYSA-N

Data  16 KI  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50263495   

TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in Hartley guinea pig brain cortex after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]-citalopram from SERT in Sprague-Dawley rat midbrain after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataEC50:  148nMAssay Description:Agonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphaq activation after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 170nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced RLuc8-f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataEC50:  186nMAssay Description:Agonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as RLuc8-fused Galphaq activation after 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  224nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1B adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  257nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1A adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  302nMAssay Description:Displacement of [3H]prazosin from human recombinant alpha-1D adrenergic receptor expressed in CHO cell membranes after 30 mins by liquid scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  363nMAssay Description:Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  447nMAssay Description:Displacement of [3H]WIN 35,428 from DAT in Sprague-Dawley rat striatum after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 575nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced mVenus-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  724nMAssay Description:Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  912nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced mVen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 1.23E+3nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced mVen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 2.63E+3nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M1 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced RLuc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  3.02E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M5(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  3.72E+3nMAssay Description:Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataIC50: 8.51E+3nMAssay Description:Antagonist activity at human SP/Myc epitope-tagged muscarinic M4 receptor expressed in HEK293T cells assessed as inhibition of carbachol-induced RLuc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  9.55E+3nMAssay Description:Displacement of [3H]CGP12177 from human recombinant beta2 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by beta counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Camerino

Curated by ChEMBL
LigandPNGBDBM50263495(CHEMBL4072818)
Affinity DataKi:  1.02E+4nMAssay Description:Displacement of [3H]CGP12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cell membranes after 90 mins by beta counting metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details Article
PubMed