BDBM50263625 CHEMBL4060895

SMILES Fc1ccc(cn1)-n1ncc(n1)C(=O)N[C@@H](Cc1ccc(OC(F)(F)F)c(Cl)c1)C(=O)NC1(CC1)C#N

InChI Key InChIKey=BOVUCBVHLWEVEP-HNNXBMFYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50263625   

TargetCysteine protease(Trypanosoma brucei rhodesiense)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263625(CHEMBL4060895)
Affinity DataKi:  14nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain using Cbz-Phe-Arg-AMC as substrate by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263625(CHEMBL4060895)
Affinity DataKi:  143nMAssay Description:Inhibition of human CatL using Cbz-Phe-Arg-AMC as substrate measured over 30 mins by fluorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263625(CHEMBL4060895)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using DBF as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263625(CHEMBL4060895)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using AMMC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM50263625(CHEMBL4060895)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed