BDBM50264310 1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-7-yl)-1H-pyrrole-2-carbonitrile::CHEMBL522432

SMILES Cn1c(ccc1-c1ccc2NC(=O)COC(C)(c3ccsc3)c2c1)C#N

InChI Key InChIKey=OPPYDCXBDREGJT-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50264310   

TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataEC50:  0.800nMAssay Description:Activity at progesterone receptor assessed as alkaline phosphatase activity in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50: 3.40nMAssay Description:Displacement of [3H]progesterone from progesterone receptor in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50: 127nMAssay Description:Antagonist activity at glucocorticoid receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50: 325nMAssay Description:Antagonist activity at androgen receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50: 440nMAssay Description:Antagonist activity at mineralocorticoid receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50264310(1-methyl-5-(5-methyl-2-oxo-5-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at estrogen receptor by Gal4-DNA binding domain-hormone receptor LBD one-hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed