BDBM50264756 CHEMBL485286::N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)phenyl)-2-(pyrrolidin-1-yl)isonicotinamide

SMILES Cc1ccc(NC(=O)c2ccnc(c2)N2CCCC2)cc1-c1ccc2c(noc2c1)C1CCNCC1

InChI Key InChIKey=DMTJDVSGJMJVRQ-UHFFFAOYSA-N

Data  1 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50264756   

TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataKi:  0.800nMAssay Description:Displacement of fluorescent ATP competitive ligand from p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MEK1 by cRaf/mek/Erk cascade assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of cFMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of ErbB4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50264756(N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-...)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMed