BDBM50265545 CHEMBL500903::N-[1-(1-Isobutyryl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

SMILES CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1

InChI Key InChIKey=JFPHZEPZNXSNSJ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265545   

TargetSecreted frizzled-related protein 1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265545(N-[1-(1-Isobutyryl-L-prolyl)piperidin-4-yl]-5-(phe...)
Affinity DataIC50: 40nMAssay Description:Binding affinity to human purified SARP2 by fluorescent polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProto-oncogene Wnt-3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265545(N-[1-(1-Isobutyryl-L-prolyl)piperidin-4-yl]-5-(phe...)
Affinity DataEC50:  90nMAssay Description:Antagonist activity at human WNT3 expressed in human U2OS cells assessed as Wnt signaling after 16 to 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed