BDBM50266686 1-tosyl-1H-pyrrole::1-tosyl-pyrrole::CA inhibitor, 13::CHEMBL508732

SMILES Cc1ccc(cc1)S(=O)(=O)n1cccc1

InChI Key InChIKey=OXWIEWFMRVJGNY-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50266686   

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50266686(1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibito...)
Affinity DataKi:  779nM ΔG°:  -8.33kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50266686(1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibito...)
Affinity DataKi:  6.01E+3nM ΔG°:  -7.12kcal/molepH: 7.5 T: 2°CAssay Description:An applied photophysics stopped flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity [Khalifah et al., J. Biol. Chem., ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50266686(1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibito...)
Affinity DataKi:  3.75E+4nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 2 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

LigandPNGBDBM50266686(1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibito...)
Affinity DataKi:  4.24E+4nMAssay Description:Inhibition of esterase activity of human carbonic anhydrase 1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Mus musculus)
University Of Massachusetts

Curated by ChEMBL
LigandPNGBDBM50266686(1-tosyl-1H-pyrrole | 1-tosyl-pyrrole | CA inhibito...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed