BDBM50267234 Acrofolione A

SMILES COc1c(CC=C(C)C)c(O)c(C(CC(C)C)c2c(O)c(C(C)=O)c(O)c3c2OC(C(C)(C)O)C3)c(O)c1C(C)=O

InChI Key InChIKey=JUCYRWSTYCKABX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50267234   

TargetProstaglandin E synthase(Human)
University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50267234BDBM50267234(Acrofolione A)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human A549 cell microsomal membrane-derived mPGES-1 assessed as reduction in conversion of PGH2 to PGE2 preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50267234BDBM50267234(Acrofolione A)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human recombinant 5-LO expressed in Escherichia coli MV1190 using arachidonic acid as substrate preincubated for 10 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50267234BDBM50267234(Acrofolione A)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of 5-LO in human peripheral blood neutrophils using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed