BDBM50267849 CHEMBL4069127
SMILES COc1cc(ccn1)-c1cc2c(N[C@@H]3CC[C@](C)(N)C3(C)C)c(cnn2c1)C(N)=O
InChI Key InChIKey=GZRWSOZXUNJKDO-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50267849
TargetTyrosine-protein kinase JAK1(Human)
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of His-tagged TYK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Human)
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of GST-tagged JAK2 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of JAK1/JAK3 in human whole blood assessed as reduction in IL-2 induced IFN-gamma production after 18 hrs by ELISAMore data for this Ligand-Target Pair