BDBM50269001 (1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-2-(4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide::CHEMBL497222

SMILES CN1CCN(CC1)C(=O)CC1CC[C@@H]([C@H](C1)C(=O)NO)C(=O)N1CCN(CC1)c1ccccc1

InChI Key InChIKey=AVCGYVHCLDMOAW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50269001   

LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant ADAM10More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 68nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of HER2 extracellular domain sheddase activity in human BT474 cells after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MMP3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Incyte

Curated by ChEMBL
LigandPNGBDBM50269001((1S,2S,5RS)-N-hydroxy-5-(2-(4-methylpiperazin-1-yl...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed