BDBM50269561 CHEMBL4097247

SMILES COCCC(=O)N1CCO[C@H](C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12

InChI Key InChIKey=BISLLWYETURXRJ-LJQANCHMSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50269561   

TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL

LigandBDBM50269561(CHEMBL4097247)Copy SMILESCopy InChI

Affinity DataIC50:  3.30nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetTyrosine-protein kinase BTK(Human)
Merck

Curated by ChEMBL

LigandBDBM50269561(CHEMBL4097247)Copy SMILESCopy InChI

Affinity DataIC50:  58nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50269561(CHEMBL4097247)Copy SMILESCopy InChI

Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI
Copy reaction URL