BDBM50269655 CHEMBL4098948

SMILES COc1ccc2c(c1)[C@]13CCN(S(=O)(=O)c4ccccc4)[C@H](C2)[C@]1(O)CC[C@H](N(C)C(=O)/C=C/c1ccoc1)C3

InChI Key InChIKey=QYOLBCOBEOPTAE-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50269655   

TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269655BDBM50269655(CHEMBL4098948)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human OX1 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetOrexin/Hypocretin receptor type 1(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269655BDBM50269655(CHEMBL4098948)
Affinity DataKi:  11nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269655BDBM50269655(CHEMBL4098948)
Affinity DataKi:  294nMAssay Description:Antagonist activity at human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular Ca2+ release preincubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
University of Tsukuba

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269655BDBM50269655(CHEMBL4098948)
Affinity DataKi:  294nMAssay Description:Antagonist activity at human OX2 receptor expressed in CHOK1 cells assessed as inhibition of orexin-A-induced calcium mobilization preincubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed