BDBM50269979 CHEMBL515170::r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-5-(trifluoromethyl)benzo[e][1,4]-oxazepin-2(1H,3H,5H)-one

SMILES CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F

InChI Key InChIKey=MSJCAWWJIHDUAU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50269979   

TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 990nMAssay Description:Displacement of [125I]DPC-AJ1951 from PTH/PTH-related peptide receptor expressed in HKRK-B28 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 5.78E+3nMAssay Description:Antagonist activity at PTH/PTH-related peptide receptor expressed in HKRK-B28 cells assessed as inhibition of DPC-AJ1951-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of adrenergic Alpha-2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of adrenergic Alpha-1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of neurokinin 2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetParathyroid hormone/parathyroid hormone-related peptide receptor(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50269979(r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-...)
Affinity DataIC50: 6.80E+4nMAssay Description:Antagonist activity at PTH/PTH-related peptide receptor expressed in HKRK-B28 cells assessed as inhibition of parathyroid hormone (1 to 34)-induced c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed