BDBM50271859 CHEMBL451218::N1-((1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-((S)-3-oxo-4-propylpiperazin-2-yl)propan-2-yl)-5-methyl-N3,N3-dipropylisophthalamide

SMILES CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@@H]1NCCN(CCC)C1=O

InChI Key InChIKey=GKMLMHBHJMGYTA-KCHLEUMXSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50271859   

TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271859(CHEMBL451218 | N1-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataIC50:  44nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50271859(CHEMBL451218 | N1-((1S,2S)-3-(3,5-difluorophenyl)-...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of BACE1 in HEK293 cells transfected with human APP cDNA containing Swedish ad London FAD mutant assessed as inhibition of amyloid beta 1-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed