BDBM50271974 CHEMBL4128457

SMILES C[C@@H]1CC(=O)Nc2ncnc(N3CCC(CC3)c3nc(cn3CCN3CCCC3)-c3ccc(F)c(c3)C(F)(F)F)c12

InChI Key InChIKey=XIYKGCYSJCRNDN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50271974   Sort by

TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant AKT1 expressed in insect cells incubated for 60 mins measured at apparent ATP Km level by kinase ADP-FP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 35nMAssay Description:Inhibition of human p70S6K measured at apparent ATP Km levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRho-associated protein kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of histidine-tagged human recombinant ROCK2 (11 to 552 residues) expressed in insect cells using RFARKGSLRQKNV substrate incubated for 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetProtein kinase C beta type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 36nMAssay Description:Inhibition of human PKCbeta2 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 20nMAssay Description:Inhibition of human RSK1 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271974(CHEMBL4128457)
Affinity DataIC50: 39nMAssay Description:Inhibition of AKT1 in human U87MG cells assessed as reduction in GSK3beta Ser9 phosphorylation incubated for 1 hr by alpha screen Surefire assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed