BDBM50271975 CHEMBL4129817

SMILES C[C@@H]1CC(=O)Nc2ncnc(N3CCC(CC3)c3nc(cn3CCN3CCCC3)C(F)(F)F)c12

InChI Key InChIKey=WABHLXQVOYVYTI-OAHLLOKOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50271975   

TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant AKT1 expressed in insect cells incubated for 60 mins measured at apparent ATP Km level by kinase ADP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50:  876nMAssay Description:Inhibition of human p70S6K measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50:  2.46E+3nMAssay Description:Inhibition of AKT1 in human U87MG cells assessed as reduction in GSK3beta Ser9 phosphorylation incubated for 1 hr by alpha screen Surefire assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibition of human PKCbeta2 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50:  272nMAssay Description:Inhibition of human RSK1 measured at apparent ATP Km levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50271975(CHEMBL4129817)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of histidine-tagged human recombinant ROCK2 (11 to 552 residues) expressed in insect cells using RFARKGSLRQKNV substrate incubated for 60 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed