BDBM50272748 ((3S,4S)-4-(2,3-dimethylphenoxy)-3,4-dihydro-1H-isochromen-3-yl)-N-methylmethanamine::CHEMBL498482

SMILES CNC[C@@H]1OCc2ccccc2[C@@H]1Oc1cccc(C)c1C

InChI Key InChIKey=JMYADEOPJFRDDM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272748   

TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272748(((3S,4S)-4-(2,3-dimethylphenoxy)-3,4-dihydro-1H-is...)
Affinity DataIC50: 39nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272748(((3S,4S)-4-(2,3-dimethylphenoxy)-3,4-dihydro-1H-is...)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant CYP32D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272748(((3S,4S)-4-(2,3-dimethylphenoxy)-3,4-dihydro-1H-is...)
Affinity DataIC50: 300nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50272748(((3S,4S)-4-(2,3-dimethylphenoxy)-3,4-dihydro-1H-is...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed