BDBM50272808 CHEMBL497863::N-[1-(3-Fluoro-benzyl)-1H-indazol-5-yl]-5-[(2,2,2-trifluoro-ethyl)-hydrazonomethyl]-pyrimidine-4,6-diamine

SMILES Nc1ncnc(Nc2ccc3n(Cc4cccc(F)c4)ncc3c2)c1CN=NCC(F)(F)F

InChI Key InChIKey=WAEKMWDUWGUADN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50272808   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272808(CHEMBL497863 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human ErbB2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272808(CHEMBL497863 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5...)
Affinity DataIC50:  258nMAssay Description:Inhibition of human ErB2 phosphorylation in human SKBR3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50272808(CHEMBL497863 | N-[1-(3-Fluoro-benzyl)-1H-indazol-5...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human EGFR expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed