BDBM50273175 CHEMBL446545::N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1-(3,4,5-trifluorophenyl)piperidine-4-carboxamide

SMILES OCCC1Oc2ccc(NC(=O)C3CCN(CC3)c3cc(F)c(F)c(F)c3)cc2NC1=O

InChI Key InChIKey=OSJROQUTACPGAR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273175   

TargetTransient receptor potential cation channel subfamily V member 1(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273175(N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium flux by FLIPRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273175(N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50273175(N-(2-(2-hydroxyethyl)-3-oxo-3,4-dihydro-2H-benzo[b...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed