BDBM50274627 CHEMBL483581::N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-1H-1,3-benzodiazol-5-yl]-4-fluoro-N-methylbenzamide

SMILES CN(C(=O)c1ccc(F)cc1)c1ccc2n(CCC(N)=O)c(NC(=O)c3ccc(cc3)C#N)nc2c1

InChI Key InChIKey=IOQHKVXGXHYAJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50274627   

TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274627(N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant ITK by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274627(N-[1-(2-carbamoylethyl)-2-[(4-cyanobenzene)amido]-...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human ITK expressed in chicken DT40 cells assessed as B cell receptor-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed