BDBM50274640 CHEMBL4126445
SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C
InChI Key InChIKey=CNCRCDLWUGCPSJ-LBPRGKRZSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50274640
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110delta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110alpha/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human 6His-tagged PI3Kgamma (144 to 1102 residues) using DiC8-PIP2 as substrate preincubated for 10 mins followed by substr...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human 6His-tagged PI3K p110beta/p85alpha using DiC8-PIP2 as substrate preincubated for 10 mins followed by substrate additi...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264 cells assessed as reduction in Akt phosphorylation at Ser473 residue preincubated for 15 mins followed by C5a...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Inhibition of PI3Kgamma in human THP-1 cells assessed as reduction in Akt phosphorylation at S473 residue incubated for 60 mins by alphalisa assayMore data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Inhibition of recombinant human full length GST-tagged CLK4 expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110alpha/human p85alpha co- expressed in Sf9 insect cells using phosphatidyl...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant N-terminal FLAG-tagged full-length human PI3K p110beta/human p85alpha co- expressed in Sf9 insect cells using phosphatidyli...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Pharmaron-Beijing
Curated by ChEMBL
Pharmaron-Beijing
Curated by ChEMBL
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged full-length human PI3K p110delta/p85alpha co- expressed in Sf9 insect cells using phosphatidylinosito...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length GST-tagged DRAK1 expressed in baculovirus expression systemMore data for this Ligand-Target Pair