BDBM50275362 CHEMBL521193::N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)nicotinamide

SMILES Nc1ccc(cc1NC(=O)c1ccc(nc1)N1CCC2(CC1)N(CNC2=O)c1ccccc1)-c1cccs1

InChI Key InChIKey=PXEWZGVZHBQFDU-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50275362   

TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275362(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(4-oxo-1-phe...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275362(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(4-oxo-1-phe...)
Affinity DataKi:  6.33E+3nMAssay Description:Displacement of [35S]MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed