BDBM50275642 2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)piperidine-1-carbonyl)thiophen-2-yl)ethanone::CHEMBL485771

SMILES FC(F)(F)C(=O)c1ccc(s1)C(=O)N1CCC(CC1)c1nnc(o1)-c1ccccc1

InChI Key InChIKey=ZSGSJOKPFNUESJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50275642   Sort by

TargetHistone deacetylase 1(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of HDAC1 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 3(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of HDAC3 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone deacetylase 6(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 160nMAssay Description:Inhibition of HDAC6 purified from HEK293 cells by Western blotMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50275642(2,2,2-trifluoro-1-(5-(4-(5-phenyl-1,3,4-oxadiazol-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C9 in human hepatocytes in presence of 10% fetal bovine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed