BDBM50275736 6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d]imidazole::CHEMBL502335

SMILES COc1ccc2nc(SCc3ccc4ccccc4c3)[nH]c2c1

InChI Key InChIKey=WSFARKDYYPRFAQ-UHFFFAOYSA-N

Data  1 KI  8 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50275736   

TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataKi:  60nMAssay Description:Inhibition of recombinant CYP2C19 using 3-O-methylfluorescein as substrate preincubated for 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C8(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  510nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2E1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  3.11E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetBombesin receptor subtype-3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataEC50: >3.20E+4nMAssay Description:Agonist activity at recombinant BRS-3 receptor (unknown origin) expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2B6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2C19(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mpheytoin as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  2.73E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50275736(6-methoxy-2-(naphthalen-2-ylmethylthio)-1H-benzo[d...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin preincubated for 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed