BDBM50278836 CHEMBL523586::N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-bromo-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide

SMILES NC[C@H](Cc1cccc(F)c1)NC(=O)c1cc(Br)c(s1)-c1ccnc2[nH]ccc12

InChI Key InChIKey=KEBMSGAJMPWLNS-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50278836   

TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 40nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 794nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MAPKAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50278836(N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-4-br...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed