BDBM50279059 CHEMBL496851::cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-pyridazin-3-yl]-1H-indole Bis-p-toluenesulfonate

SMILES CN1C[C@H]2CN(C[C@H]2C1)c1ccc(nn1)-c1ccc2[nH]ccc2c1

InChI Key InChIKey=QLRNTKYYDKUMQG-UHFFFAOYSA-N

Data  2 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50279059   

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279059(cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]A585539 from alpha7 nicotinic acetylcholine receptor in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279059(cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-...)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human recombinant alpha7 nicotinic acetylcholine receptor expressed in xenopus laevis oocytes by parallel oocyte electrophysiolog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279059(cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50279059(cis-5-[6-(5-Methyl-hexahydro-pyrrolo[3,4-c]pyrrol-...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human recombinant alpha4beta2 nicotinic acetylcholine receptor expressed in HEK293 cells assessed as changes in intracellular cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed