BDBM50279570 CHEMBL4165845

SMILES OC1CCC(CC1)C1=C(c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c2ccc(O)cc2CCC1

InChI Key InChIKey=ORNJMAUSEXCFFI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50279570   

TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed