BDBM50280395 CHEMBL4171480

SMILES C[C@@H]1CCc2c(Br)c(F)c(Br)cc2N1C=O

InChI Key InChIKey=ZZLQPWXVZCPUGC-UHFFFAOYSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50280395   

TargetRap guanine nucleotide exchange factor 3(Human)
Institute For Research In Cancer and Allied Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
Institute For Research In Cancer and Allied Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at recombinant human GST-fused EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta (DE3) assessed as inhibition of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
Institute For Research In Cancer and Allied Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at recombinant full length EPAC2 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2020
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
Institute For Research In Cancer and Allied Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataKd:  1.24E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRap guanine nucleotide exchange factor 3(Human)
Institute For Research In Cancer and Allied Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280395BDBM50280395(CHEMBL4171480)
Affinity DataKd:  7.57E+5nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) in presence of human serum albumin by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed