BDBM50280581 CHEMBL4172148

SMILES N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1CC2CN(Cc3c[nH]c4ccc(Cl)cc34)CC2C1

InChI Key InChIKey=HTHTZBDFQBOXDD-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50280581   

TargetSon of sevenless homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50280581(CHEMBL4172148)
Affinity DataEC50:  6.70E+3nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50280581(CHEMBL4172148)
Affinity DataEC50:  6.70E+3nMAssay Description:Binding affinity to human recombinant N-terminal His6-tagged SOS1 (564 to 1049 residues) expressed in BL21-RIL Escherichia coli assessed as SOS1-RAS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2020
Entry Details Article
PubMed