BDBM50287307 CHEMBL4176554::US10759787, Example 6::US11059811, Example 6

SMILES CCc1c(N(CC)C2CCOCC2)cc2oc(CN3CCOCC3)cc2c1C(=O)NCc1c(OC)cc(C)[nH]c1=O

InChI Key InChIKey=HGVOGVKCDOMMKJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50287307   

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50287307BDBM50287307(CHEMBL4176554 | US10759787, Example 6 | US11059811...)
Affinity DataIC50: 7.80nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Jiangsu Hengrui Medicine

US Patent
LigandChemical structure of BindingDB Monomer ID 50287307BDBM50287307(CHEMBL4176554 | US10759787, Example 6 | US11059811...)
Affinity DataIC50: 7.80nMAssay Description:The activity of EZH2 enzyme (with A677G mutant or Y641F mutant) was tested by the following method.The method was used to determine the inhibitory ef...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50287307BDBM50287307(CHEMBL4176554 | US10759787, Example 6 | US11059811...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2020
Entry Details Article
PubMed