BDBM50291523 3-Chloro-6-(3-chloro-4-cyano-phenyl)-pyridazine-4-carboxylic acid amide::CHEMBL6429

SMILES NC(=O)c1cc(nnc1Cl)-c1ccc(C#N)c(Cl)c1

InChI Key InChIKey=VAMYFJTZLUVTRH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50291523   

TargetCaspase-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291523(3-Chloro-6-(3-chloro-4-cyano-phenyl)-pyridazine-4-...)
Affinity DataIC50: 500nMAssay Description:Antiinflammatory activity measured as the concentration required to inhibit IL-1 beta converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCaspase-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50291523(3-Chloro-6-(3-chloro-4-cyano-phenyl)-pyridazine-4-...)
Affinity DataIC50: 500nMAssay Description:Inhibition of caspase-1 (unknown origin) using Ac-Tyr-Val-Ala-Asp-AFC as fluorogenic substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed