BDBM50291960 CHEMBL1254461

SMILES Brc1ccccc1\C=C1/CNC\C(=C/c2ccccc2Br)C1=O

InChI Key InChIKey=SRIXJFUIIDOCNK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50291960   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50291960(CHEMBL1254461)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant DYRK2 using KKISGRLSPIMTEQ as substrate incubated for 60 mins in the presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
The First Affiliated Hospital of Wenzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50291960(CHEMBL1254461)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of IKKbeta (unknown origin) using FAM-P22 as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2020
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Sun Yat-sen University

Curated by ChEMBL
LigandPNGBDBM50291960(CHEMBL1254461)
Affinity DataKd:  7.90E+3nMAssay Description:Binding affinity to DYRK2 (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed