BDBM50293176 (trans)-4-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-ylamino)cyclohexanol::CHEMBL495557

SMILES CC(C)(C)c1cnc(CSc2cnc(N[C@H]3CC[C@H](O)CC3)s2)o1

InChI Key InChIKey=SYPGWQCWWXBNKA-HAQNSBGRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50293176   

TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293176((trans)-4-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK2/cyclin A by IMAP florescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293176((trans)-4-(5-((5-tert-butyloxazol-2-yl)methylthio)...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of CDK9 in human HCT116 cells assessed as phosphor-ser2 level of RNA polymerase 2 after 16 hrs by high content cellular assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed