BDBM50296527 CHEMBL552269::N-(5-(3,5-difluorobenzyl)thiazol-2-yl)-3-(2-hydroxyethoxy)-4-methoxybenzamide

SMILES COc1ccc(cc1OCCO)C(=O)Nc1ncc(Cc2cc(F)cc(F)c2)s1

InChI Key InChIKey=ATESJOJGSWWETO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50296527   

TargetAcyl-CoA desaturase 1(Mouse)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296527(CHEMBL552269 | N-(5-(3,5-difluorobenzyl)thiazol-2-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of SCD1 in mouse microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296527(CHEMBL552269 | N-(5-(3,5-difluorobenzyl)thiazol-2-...)
Affinity DataIC50:  116nMAssay Description:Inhibition of human SCD1 expressed in HEK293A cells assessed as conversion of [14C]stearate to [14C]oleateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStearoyl-CoA desaturase(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50296527(CHEMBL552269 | N-(5-(3,5-difluorobenzyl)thiazol-2-...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of SCD1 in human microsomes assessed as conversion of [14C]stearate to [14C]oleate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed