BDBM50297386 3-(3-(tert-butylthio)-1-(3-(6-methoxypyridin-3-yl)benzyl)-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid::CHEMBL538708

SMILES COc1ccc(cn1)-c1cccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)c1

InChI Key InChIKey=KGMBHQHCFFDTJI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50297386   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297386(3-(3-(tert-butylthio)-1-(3-(6-methoxypyridin-3-yl)...)
Affinity DataIC50: 5.5nMAssay Description:Displacement of [3H]3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzyl-indol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297386(3-(3-(tert-butylthio)-1-(3-(6-methoxypyridin-3-yl)...)
Affinity DataIC50: 420nMAssay Description:Inhibition of COX1 in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed